Chemicals and Drugs

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine

A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.

Chemical Identity

Chemical Information

Molecular Formula
C14H17N3O2S
Molecular Weight
291.37 g/mol
IUPAC Name
5-[(2S)-2-methylpiperazin-1-yl]sulfonylisoquinoline
InChIKey
BDVFVCGFMNCYPV-NSHDSACASA-N
SMILES
C[C@H]1CNCCN1S(=O)(=O)C2=CC=CC3=C2C=CN=C3
MeSH Unique ID
D019307
Source
PubChem CID 449240

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

3 entry terms
  • 1-(5-Isoquinolinylsulfonyl)-2-Methylpiperazine
  • H-7
  • H 7

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

97; was 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE (NM) 1985-96

MeSH Record

Previous Indexing

  • Isoquinolines (1985-1996)
  • Piperazines (1985-1996)

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.590w.700w.545
  2. D03w.383.606w.527
  3. D03w.633.100.531.400

AMA Style

References

  1. National Library of Medicine. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine. Medical Subject Headings (MeSH). 2026. Unique ID D019307. http://id.nlm.nih.gov/mesh/2026/D019307
  2. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine. In: Wikidata. https://www.wikidata.org/wiki/Q27097224
  3. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine. In: PubChem Compound. CID 449240. https://pubchem.ncbi.nlm.nih.gov/compound/449240