Chemicals and Drugs

1-Alkyl-2-acetylglycerophosphocholine Esterase

A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

24 entry terms
  • Lipoprotein-Associated Phospholipase A(2)
  • Lipoprotein-Associated Phospholipase A2
  • Lp-PLA(2)
  • Lp-PLA2
  • PAF 2-Acetylhydrolase
  • PAF 2-Acylhydrolase
  • PAF Acetylhydrolase
  • PAF Acetylhydrolase II
  • Platelet-Activating Factor Hydrolase
  • 1 Alkyl 2 acetylglycerophosphocholine Esterase
  • 2-Acetylhydrolase, PAF
  • Acetylhydrolase II, PAF
  • Acetylhydrolase, PAF
  • Esterase, 1-Alkyl-2-acetylglycerophosphocholine
  • Factor Hydrolase, Platelet-Activating
  • Hydrolase, Platelet-Activating Factor
  • Lipoprotein Associated Phospholipase A2
  • Lp PLA2
  • PAF 2 Acetylhydrolase
  • PAF 2 Acylhydrolase
  • Phospholipase A2, Lipoprotein-Associated
  • Platelet Activating Factor Hydrolase
  • Platelet-activating Factor Acetylhydrolase IB
  • Platelet activating Factor Acetylhydrolase IB

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

/antag: coordinate with PHOSPHOLIPASE A2 INHIBITORS

MeSH Record

History Note

2004(1983)

MeSH Record

Previous Indexing

  • Phospholipases (1983-2003)

MeSH Hierarchy

Tree Number

  1. D08.811w.277w.352w.100.680w.750.937w.249w

AMA Style

References

  1. National Library of Medicine. 1-Alkyl-2-acetylglycerophosphocholine Esterase. Medical Subject Headings (MeSH). 2026. Unique ID D043203. http://id.nlm.nih.gov/mesh/2026/D043203
  2. 1-Alkyl-2-acetylglycerophosphocholine Esterase. In: Wikipedia. https://en.wikipedia.org/wiki/1-alkyl-2-acetylglycerophosphocholine_esterase
  3. 1-Alkyl-2-acetylglycerophosphocholine Esterase. In: Wikidata. https://www.wikidata.org/wiki/Q4545809