Structured Summary
Abstract
A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
6 entry terms
- 12-HETE
- 12-R-HETE
- 12-S-HETE
- 12-S-Hydroxyeicosatetraenoic Acid
- 12 S Hydroxyeicosatetraenoic Acid
- Acid, 12-S-Hydroxyeicosatetraenoic
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
97; was 12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID (NM) 1975-96
MeSH Record
Previous Indexing
- Arachidonic Acids (1975-1984)
- Fatty Alcohols (1975-1976)
- Hydroxy Acids (1976-1978)
- Hydroxyeicosatetraenoic Acids (1985-1996)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid. Medical Subject Headings (MeSH). 2026. Unique ID D019377. http://id.nlm.nih.gov/mesh/2026/D019377
- 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid. In: Wikidata. https://www.wikidata.org/wiki/Q27109114