Structured Summary
Abstract
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
MeSH Record
Classification
Broader headings
Related Concepts
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
12 entry terms
- 2-APV
- 2-Amino-5-phosphonopentanoate
- 2-Amino-5-phosphonopentanoic Acid
- 2-Amino-5-phosphonovaleric Acid
- 5-Phosphononorvaline
- 2 Amino 5 phosphonopentanoate
- 2 Amino 5 phosphonopentanoic Acid
- 2 Amino 5 phosphonovalerate
- 2 Amino 5 phosphonovaleric Acid
- 5 Phosphononorvaline
- d-APV
- dl-APV
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
90
MeSH Record
Previous Indexing
- Anticonvulsants (1966-1989)
- Valine (1966-1974)
- Valine/analogs & derivatives (1975-1989)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. 2-Amino-5-phosphonovalerate. Medical Subject Headings (MeSH). 2026. Unique ID D015763. http://id.nlm.nih.gov/mesh/2026/D015763
- 2-Amino-5-phosphonovalerate. In: Wikidata. https://www.wikidata.org/wiki/Q27105144