Chemicals and Drugs

25-Hydroxyvitamin D 2

9,10-Secoergosta-5,7,10(19),22-tetraene-3,25-diol. Biologically active metabolite of vitamin D2 which is more active in curing rickets than its parent. The compound is believed to attach to the same receptor as vitamin D2 and 25-hydroxyvitamin D3.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

9,10-Secoergosta-5,7,10(19),22-tetraene-3,25-diol. Biologically active metabolite of vitamin D2 which is more active in curing rickets than its parent. The compound is believed to attach to the same receptor as vitamin D2 and 25-hydroxyvitamin D3.

Chemical Identity

Chemical Information

Molecular Formula
C28H44O2
Molecular Weight
412.6 g/mol
CAS Registry No.
21343-40-8
IUPAC Name
(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
InChIKey
KJKIIUAXZGLUND-ICCVIKJNSA-N
SMILES
C[C@H](/C=C/[C@H](C)C(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](CCC3=C)O)C
MeSH Unique ID
D015652
Source
PubChem CID 5710148

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • 25-Hydroxycalciferol
  • 25-Hydroxyergocalciferol
  • 25-Hydroxyvitamin D2
  • 9,10-Secoergosta-5,7,10(19),22-tetraene-3 beta,25-diol
  • Ercalcidiol
  • 25 Hydroxycalciferol
  • 25 Hydroxyergocalciferol
  • 25 Hydroxyvitamin D 2
  • 25 Hydroxyvitamin D2

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

deficiency: coordinate 25-HYDROXYVITAMIN D 2 /defic (IM) with RICKETS (IM) or with VITAMIN D DEFICIENCY (IM)

MeSH Record

History Note

90

MeSH Record

Previous Indexing

  • Ergocalciferols (1966-1989)

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.247.222w.474.400
  2. D04w.210.500w.247.808w.412.400
  3. D04w.210.500w.812w.768w.462.400
  4. D10w.570w.938w.439.500

AMA Style

References

  1. National Library of Medicine. 25-Hydroxyvitamin D 2. Medical Subject Headings (MeSH). 2026. Unique ID D015652. http://id.nlm.nih.gov/mesh/2026/D015652
  2. 25-Hydroxyvitamin D 2. In: Wikidata. https://www.wikidata.org/wiki/Q27159079
  3. 25-Hydroxyvitamin D 2. In: PubChem Compound. CID 5710148. https://pubchem.ncbi.nlm.nih.gov/compound/5710148