Chemicals and Drugs

3-Iodobenzylguanidine

A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.

Chemical Identity

Chemical Information

Molecular Formula
C8H10IN3
Molecular Weight
275.09 g/mol
CAS Registry No.
80663-95-2
IUPAC Name
2-[(3-iodophenyl)methyl]guanidine
InChIKey
PDWUPXJEEYOOTR-UHFFFAOYSA-N
SMILES
C1=CC(=CC(=C1)I)CN=C(N)N
MeSH Unique ID
D019797
Source
PubChem CID 60860

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

15 entry terms
  • Iobenguane
  • MIBG
  • m-Iodobenzylguanidine
  • meta-Iodobenzylguanidine
  • 3 Iodobenzylguanidine
  • m Iodobenzylguanidine
  • meta Iodobenzylguanidine
  • (3-Iodo-(131I)benzyl)guanidine
  • 3-Iodobenzylguanidine, 123I Labeled
  • 3-Iodobenzylguanidine, 125I Labeled
  • Iobenguane (131I)
  • 123I Labeled 3-Iodobenzylguanidine
  • 125I Labeled 3-Iodobenzylguanidine
  • 3 Iodobenzylguanidine, 123I Labeled
  • 3 Iodobenzylguanidine, 125I Labeled

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

98; use 3-IODOBENZYLGUANIDINE (NM) 1980-97

MeSH Record

Previous Indexing

  • Guanidines (1980-1982)
  • Iodobenzenes (1983-1997)

MeSH Hierarchy

Tree Numbers

  1. D02w.078w.370.510
  2. D02w.455w.426w.559w.389.454.300
  3. D02w.455w.526.581.496.300

AMA Style

References

  1. National Library of Medicine. 3-Iodobenzylguanidine. Medical Subject Headings (MeSH). 2026. Unique ID D019797. http://id.nlm.nih.gov/mesh/2026/D019797
  2. 3-Iodobenzylguanidine. In: Wikidata. https://www.wikidata.org/wiki/Q3154058
  3. 3-Iodobenzylguanidine. In: PubChem Compound. CID 60860. https://pubchem.ncbi.nlm.nih.gov/compound/60860