Chemicals and Drugs

4-Butyrolactone

One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.

Chemical Identity

Chemical Information

Molecular Formula
C4H6O2
Molecular Weight
86.09 g/mol
CAS Registry No.
96-48-0
IUPAC Name
oxolan-2-one
InChIKey
YEJRWHAVMIAJKC-UHFFFAOYSA-N
SMILES
C1CC(=O)OC1
MeSH Unique ID
D015107
Source
PubChem CID 7302

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

11 entry terms
  • 1,4-Butanolide
  • 4-Hydroxybutyric Acid Lactone
  • Dihydro-2(3H)-furanone
  • Furanone, tetrahydro-2-
  • gamma-Butyrolactone
  • 1,4 Butanolide
  • 4 Butyrolactone
  • 4 Hydroxybutyric Acid Lactone
  • Furanone, tetrahydro 2
  • Lactone, 4-Hydroxybutyric Acid
  • gamma Butyrolactone

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(77); was see under FURANS 1977-90; was GAMMA BUTYROLACTONE see under FURANS 1976

MeSH Record

Previous Indexing

  • Furans (1969-1975)
  • Lactones (1969-1975)

MeSH Hierarchy

Tree Numbers

  1. D02w.540w.150w
  2. D03w.383.312.150w

AMA Style

References

  1. National Library of Medicine. 4-Butyrolactone. Medical Subject Headings (MeSH). 2026. Unique ID D015107. http://id.nlm.nih.gov/mesh/2026/D015107
  2. 4-Butyrolactone. In: Wikipedia. https://en.wikipedia.org/wiki/%CE%93-Butyrolactone
  3. 4-Butyrolactone. In: Wikidata. https://www.wikidata.org/wiki/Q79739
  4. 4-Butyrolactone. In: PubChem Compound. CID 7302. https://pubchem.ncbi.nlm.nih.gov/compound/7302