Chemicals and Drugs

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase

An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC 2.1.1.13.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC 2.1.1.13.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

12 entry terms
  • Methionine Synthase
  • Methionine Synthetase
  • Methyltetrahydrofolate Homocysteine Methyltransferase
  • Tetrahydropteroylglutamate Methyltransferase
  • Homocysteine Methyltransferase, Methyltetrahydrofolate
  • Methyltransferase, Methyltetrahydrofolate Homocysteine
  • Methyltransferase, Tetrahydropteroylglutamate
  • S-Methyltransferase, 5-Methyltetrahydrofolate-Homocysteine
  • Synthase, Methionine
  • Synthetase, Methionine
  • Vitamin B12-Dependent Methionine Synthase
  • Vitamin B12-Independent Methionine Synthase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

/defic: consider also HOMOCYSTINURIA

MeSH Record

History Note

98(75)

MeSH Record

Previous Indexing

  • Methionine (1973-1974)
  • Methyltransferases (1973-1974)
  • Tetrahydrofolates (1973-1974)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.555.500w.645

AMA Style

References

  1. National Library of Medicine. 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase. Medical Subject Headings (MeSH). 2026. Unique ID D013766. http://id.nlm.nih.gov/mesh/2026/D013766
  2. 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase. In: Wikidata. https://www.wikidata.org/wiki/Q24777462