Chemicals and Drugs

AAA Proteins

A large, highly conserved and functionally diverse superfamily of NTPases and nucleotide-binding proteins that are characterized by a conserved 200 to 250 amino acid nucleotide-binding and catalytic domain, the AAA+ module. They assemble into hexameric ring complexes that function in the energy-dependent remodeling of macromolecules. Members include ATPASES ASSOCIATED WITH DIVERSE CELLULAR ACTIVITIES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A large, highly conserved and functionally diverse superfamily of NTPases and nucleotide-binding proteins that are characterized by a conserved 200 to 250 amino acid nucleotide-binding and catalytic domain, the AAA+ module. They assemble into hexameric ring complexes that function in the energy-dependent remodeling of macromolecules. Members include ATPASES ASSOCIATED WITH DIVERSE CELLULAR ACTIVITIES.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

9 entry terms
  • AAA Protein
  • AAA Superfamily
  • AAA+ Superfamily
  • Protein, AAA
  • Superfamily, AAA
  • Superfamily, AAA+
  • P-Loop NTPases
  • NTPases, P-Loop
  • P Loop NTPases

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Adenosine Triphosphatases (1995-2017)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.040w.013w
  2. D12.776w.157w.025w

AMA Style

References

  1. National Library of Medicine. AAA Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D000074582. http://id.nlm.nih.gov/mesh/2026/D000074582
  2. AAA Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/AAA_proteins
  3. AAA Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q4649768