Chemicals and Drugs

A Kinase Anchor Proteins

A structurally-diverse family of intracellular-signaling adaptor proteins that selectively tether specific protein kinase A subtypes to distinct subcellular sites. They play a role in focusing the PROTEIN KINASE A activity toward relevant substrates. Over fifty members of this family exist, most of which bind specifically to regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASE TYPE II such as CAMP PROTEIN KINASE RIIALPHA or CAMP PROTEIN KINASE RIIBETA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A structurally-diverse family of intracellular-signaling adaptor proteins that selectively tether specific protein kinase A subtypes to distinct subcellular sites. They play a role in focusing the PROTEIN KINASE A activity toward relevant substrates. Over fifty members of this family exist, most of which bind specifically to regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASE TYPE II such as CAMP PROTEIN KINASE RIIALPHA or CAMP PROTEIN KINASE RIIBETA.

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Broader headings

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MeSH Record

Synonyms

9 entry terms
  • A-Kinase Anchor Proteins
  • A-Kinase Anchoring Protein
  • A-Kinase Anchoring Proteins
  • Protein Kinase A Anchor Proteins
  • A Kinase Anchoring Protein
  • A Kinase Anchoring Proteins
  • Anchor Proteins, A-Kinase
  • Anchoring Protein, A-Kinase
  • Protein, A-Kinase Anchoring

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2008

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.065w
  2. D12.776w.157w.057w.003w
  3. D12.776w.476.024w.069w

AMA Style

References

  1. National Library of Medicine. A Kinase Anchor Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D054758. http://id.nlm.nih.gov/mesh/2026/D054758
  2. A Kinase Anchor Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/A-kinase-anchoring_protein
  3. A Kinase Anchor Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q4652139