Diseases

Activated Protein C Resistance

A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.

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Classification

Broader headings

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See Also

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Synonyms

2 entry terms
  • APC Resistance
  • Resistance, APC

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

1999

MeSH Record

Previous Indexing

  • Factor V/genetics (1994-1998)
  • Protein C (1993-1998)

MeSH Hierarchy

Tree Numbers

  1. C15.378w.100w.100.037w
  2. C15.378w.100w.141.036w
  3. C15.378w.925w.050w
  4. C16w.320w.099.037w

AMA Style

References

  1. National Library of Medicine. Activated Protein C Resistance. Medical Subject Headings (MeSH). 2026. Unique ID D020016. http://id.nlm.nih.gov/mesh/2026/D020016
  2. Activated Protein C Resistance. In: Wikipedia. https://en.wikipedia.org/wiki/Activated_protein_C_resistance
  3. Activated Protein C Resistance. In: Wikidata. https://www.wikidata.org/wiki/Q296104