Chemicals and Drugs

Adenosine-5'-(N-ethylcarboxamide)

A stable adenosine A1 and A2 receptor agonist. Experimentally, it inhibits cAMP and cGMP phosphodiesterase activity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A stable adenosine A1 and A2 receptor agonist. Experimentally, it inhibits cAMP and cGMP phosphodiesterase activity.

Chemical Identity

Chemical Information

Molecular Formula
C12H16N6O4
Molecular Weight
308.29 g/mol
CAS Registry No.
35920-39-9
IUPAC Name
(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
InChIKey
JADDQZYHOWSFJD-FLNNQWSLSA-N
SMILES
CCNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O
MeSH Unique ID
D019830
Source
PubChem CID 448222

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • 5'-N-Ethylcarboxamidoadenosine
  • Adenosine-5'-N-ethyluronamide
  • N-Ethylcarboxamidoadenosine
  • N6-Ethyl-carboxamido Adenosine
  • NECA
  • 5' N Ethylcarboxamidoadenosine
  • Adenosine 5' N ethyluronamide
  • Adenosine, N6-Ethyl-carboxamido
  • N Ethylcarboxamidoadenosine
  • N6 Ethyl carboxamido Adenosine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

98; use ADENOSINE-5'-(N-ETHYLCARBOXAMIDE) (NM) 1980-97

MeSH Record

Previous Indexing

  • Adenosine/analogs & derivatives (1980-1997)

MeSH Hierarchy

Tree Numbers

  1. D03w.633.100.759.590.138w.025w
  2. D13.570w.583.138w.025w
  3. D13.570w.800w.096w.250w

AMA Style

References

  1. National Library of Medicine. Adenosine-5'-(N-ethylcarboxamide). Medical Subject Headings (MeSH). 2026. Unique ID D019830. http://id.nlm.nih.gov/mesh/2026/D019830
  2. Adenosine-5'-(N-ethylcarboxamide). In: Wikipedia. https://en.wikipedia.org/wiki/5%E2%80%B2-(N-Ethylcarboxamido)adenosine
  3. Adenosine-5'-(N-ethylcarboxamide). In: Wikidata. https://www.wikidata.org/wiki/Q27087892
  4. Adenosine-5'-(N-ethylcarboxamide). In: PubChem Compound. CID 448222. https://pubchem.ncbi.nlm.nih.gov/compound/448222