Structured Summary
Abstract
A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
3 entry terms
- ASIP Protein
- Agouti Protein
- Agouti Switch Protein
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2008 (1993)
MeSH Record
Previous Indexing
- Intercellular Signaling Peptides and Proteins (1994-2007)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Agouti Signaling Protein. Medical Subject Headings (MeSH). 2026. Unique ID D054366. http://id.nlm.nih.gov/mesh/2026/D054366
- Agouti Signaling Protein. In: Wikipedia. https://en.wikipedia.org/wiki/Agouti-signaling_protein
- Agouti Signaling Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21102066