Structured Summary
Abstract
A family of NADPH-dependent oxidoreductases that reduce carbonyl substrates including sugar-aldehydes, KETOSTEROIDS; keto-prostaglandins, and QUINONES. They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)-barrel structure that contains the NADP binding site. This conformation favors aromatic and apolar substrates.
MeSH Record
Classification
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
Synonyms
9 entry terms
- Aldo-Keto Reductase Family
- Aldo-Keto Reductase Superfamily
- Aldo Keto Reductase Family
- Aldo Keto Reductase Superfamily
- Aldo Keto Reductases
- Reductases, Aldo-Keto
- Aldo-Keto Reductase
- Aldo Keto Reductase
- Reductase, Aldo-Keto
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Aldehyde Reductase (1976-2017)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Aldo-Keto Reductases. Medical Subject Headings (MeSH). 2026. Unique ID D000074408. http://id.nlm.nih.gov/mesh/2026/D000074408
- Aldo-Keto Reductases. In: Wikipedia. https://en.wikipedia.org/wiki/Aldo-keto_reductase
- Aldo-Keto Reductases. In: Wikidata. https://www.wikidata.org/wiki/Q24782718