Chemicals and Drugs

Almitrine

A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.

Chemical Identity

Chemical Information

Molecular Formula
C26H29F2N7
Molecular Weight
477.6 g/mol
CAS Registry No.
27469-53-0
IUPAC Name
6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine
InChIKey
OBDOVFRMEYHSQB-UHFFFAOYSA-N
SMILES
C=CCNC1=NC(=NC(=N1)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)NCC=C
MeSH Unique ID
D015765
Source
PubChem CID 33887

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • Almitrine Bis(methanesulfonate)
  • Almitrine Bismesylate
  • Almitrine Dimesylate
  • Almitrine Monomesylate
  • Vectarion
  • Monomesylate, Almitrine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

90

MeSH Record

Previous Indexing

  • Analeptics (1966-1989)
  • Piperazines (1966-1989)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.606w.130w
  2. D03w.383.931w.095w

AMA Style

References

  1. National Library of Medicine. Almitrine. Medical Subject Headings (MeSH). 2026. Unique ID D015765. http://id.nlm.nih.gov/mesh/2026/D015765
  2. Almitrine. In: Wikipedia. https://en.wikipedia.org/wiki/Almitrine
  3. Almitrine. In: Wikidata. https://www.wikidata.org/wiki/Q4733858
  4. Almitrine. In: PubChem Compound. CID 33887. https://pubchem.ncbi.nlm.nih.gov/compound/33887