Chemicals and Drugs

Alpha-Ketoglutarate-Dependent Dioxygenase FTO

A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

8 entry terms
  • AlkB Homolog 9 Protein
  • Alpha-Ketoglutarate-Dependent Dioxygenase
  • Fat Mass and Obesity Associated (FTO) Protein
  • Fat Mass and Obesity Associated Protein
  • Alpha Ketoglutarate Dependent Dioxygenase
  • Alpha Ketoglutarate Dependent Dioxygenase FTO
  • Dioxygenase, Alpha-Ketoglutarate-Dependent
  • FTO, Alpha-Ketoglutarate-Dependent Dioxygenase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Mixed Function Oxygenases (2007-2016)
  • Oxo-Acid-Lyases (2007-2016)
  • Proteins (2008-2016)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.074.062.968
  2. D08.811w.682w.662.582.242
  3. D08.811w.682w.690w.416w.139.992

AMA Style

References

  1. National Library of Medicine. Alpha-Ketoglutarate-Dependent Dioxygenase FTO. Medical Subject Headings (MeSH). 2026. Unique ID D000071516. http://id.nlm.nih.gov/mesh/2026/D000071516
  2. Alpha-Ketoglutarate-Dependent Dioxygenase FTO. In: Wikidata. https://www.wikidata.org/wiki/Q24724576