Phenomena and Processes

Alternative Splicing

A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.

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Classification

Broader headings

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See Also

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Synonyms

17 entry terms
  • Alternate Splicing
  • RNA Splicing, Alternative
  • Splicing, Alternative
  • Alternate Splicings
  • Alternative RNA Splicing
  • Alternative RNA Splicings
  • Alternative Splicings
  • RNA Splicings, Alternative
  • Splicing, Alternate
  • Splicing, Alternative RNA
  • Splicings, Alternate
  • Splicings, Alternative
  • Splicings, Alternative RNA
  • Nested Transcripts
  • Nested Transcript
  • Transcript, Nested
  • Transcripts, Nested

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

MeSH Record

Indexing Annotation

for NESTED TRANSCRIPTS also index the RNA; do not confuse with NESTED GENES; for nested primers use NESTED PCR; (POLYMERASE CHAIN REACTION)

MeSH Record

History Note

93

MeSH Record

Previous Indexing

  • RNA Splicing (1982-1992)

MeSH Hierarchy

Tree Numbers

  1. G02.111.760w.700w.100w
  2. G03w.839w.700w.100w
  3. G05.308w.700w.700w.100w

AMA Style

References

  1. National Library of Medicine. Alternative Splicing. Medical Subject Headings (MeSH). 2026. Unique ID D017398. http://id.nlm.nih.gov/mesh/2026/D017398
  2. Alternative Splicing. In: Wikipedia. https://en.wikipedia.org/wiki/Alternative_splicing
  3. Alternative Splicing. In: Wikidata. https://www.wikidata.org/wiki/Q21114084