Structured Summary
Abstract
Cyclic peptides extracted from carpophores of various mushroom species. They are potent inhibitors of RNA polymerases in most eukaryotic species, blocking the production of mRNA and protein synthesis. These peptides are important in the study of transcription. Alpha-amanitin is the main toxin from the species Amanitia phalloides, poisonous if ingested by humans or animals.
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Classification
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Drug Class
Pharmacological Action
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Synonyms
1 entry terms
- Amanitin
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
Indexing Annotation
/antag permitted but consider also ANTITOXINS
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History Note
75
MeSH Record
Previous Indexing
- Mycotoxins (1974)
- Oligopeptides (1974)
- Peptides, Cyclic (1974)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Amanitins. Medical Subject Headings (MeSH). 2026. Unique ID D000546. http://id.nlm.nih.gov/mesh/2026/D000546
- Amanitins. In: Wikidata. https://www.wikidata.org/wiki/Q74563185