Chemicals and Drugs

Amphetamine

A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.

Chemical Identity

Chemical Information

Molecular Formula
C9H13N
Molecular Weight
135.21 g/mol
CAS Registry No.
300-62-9
IUPAC Name
1-phenylpropan-2-amine
InChIKey
KWTSXDURSIMDCE-UHFFFAOYSA-N
SMILES
CC(CC1=CC=CC=C1)N
MeSH Unique ID
D000661
Source
PubChem CID 3007

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

16 entry terms
  • Amfetamine
  • Desoxynorephedrin
  • Phenamine
  • Phenopromin
  • Amphetamine Sulfate
  • Amphetamine Sulfate (2:1)
  • Centramina
  • Fenamine
  • Levoamphetamine
  • Mydrial
  • Thyramine
  • l-Amphetamine
  • levo-Amphetamine
  • Sulfate, Amphetamine
  • l Amphetamine
  • levo Amphetamine

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

a specific chem: do not confuse with AMPHETAMINES; d-amphetamine = DEXTROAMPHETAMINE; N-methylamphetamine = METHAMPHETAMINE

MeSH Hierarchy

Tree Number

  1. D02w.092w.471.683w.152w.110w

AMA Style

References

  1. National Library of Medicine. Amphetamine. Medical Subject Headings (MeSH). 2026. Unique ID D000661. http://id.nlm.nih.gov/mesh/2026/D000661
  2. Amphetamine. In: Wikipedia. https://en.wikipedia.org/wiki/Amphetamine
  3. Amphetamine. In: Wikidata. https://www.wikidata.org/wiki/Q179452
  4. Amphetamine. In: PubChem Compound. CID 3007. https://pubchem.ncbi.nlm.nih.gov/compound/3007