Structured Summary
Abstract
A 77 amino acid secreted endogenous ligand for the angiotensin II receptor-like 1 protein (APELIN RECEPTOR) that is proteolytically cleaved into four smaller peptides: Apelin-36, Apelin-31, Apelin-28, and Apelin-13. It inhibits entry of HIV into cells that express both APJ and CD4 ANTIGEN and is highly expressed in breast milk, where it may modulate the neonatal immune response.
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30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
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History Note
2018
MeSH Record
Previous Indexing
- Carrier Proteins (1998-2017)
- Intercellular Signaling Peptides and Proteins (2006-2017)
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References
- National Library of Medicine. Apelin. Medical Subject Headings (MeSH). 2026. Unique ID D000073861. http://id.nlm.nih.gov/mesh/2026/D000073861
- Apelin. In: Wikidata. https://www.wikidata.org/wiki/Q24784772