Chemicals and Drugs

Apolipoprotein A-I

The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

25 entry terms
  • Apo A-1
  • Apo A-I
  • Apo A1
  • Apo AI
  • ApoA-1
  • ApoA-I
  • Apolipoprotein A-1
  • Apolipoprotein A1
  • Apolipoprotein AI
  • Apolipoprotein A 1
  • Apolipoprotein A I
  • Apo A-I Isoproteins
  • Apolipoprotein A-I Isoprotein-2
  • Apolipoprotein A-I Isoprotein-4
  • Apolipoprotein A-I Isoproteins
  • Apolipoprotein AI Propeptide
  • Pro-Apo A-I
  • Pro-Apolipoprotein A-I
  • Proapolipoprotein AI
  • Apo A I Isoproteins
  • Apolipoprotein A I Isoprotein 2
  • Apolipoprotein A I Isoprotein 4
  • Apolipoprotein A I Isoproteins
  • Pro Apo A I
  • Pro Apolipoprotein A I

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

1992 (1974); for PRO-APOLIPOPROTEIN A-I (NM) use APOLIPOPROTEINS A & PROTEIN PRECURSORS 1983-2006; for APOLIPOPROTEIN A-I ISOPROTEINS (NM) use APOLIPOPROTEINS A 1980-2006

MeSH Record

Previous Indexing

  • Apolipoproteins (1977-1984)
  • Apolipoproteins A (1985-1991)

MeSH Hierarchy

Tree Numbers

  1. D10w.532w.091w.200.100w
  2. D12.776w.070.400w.200.100w
  3. D12.776w.521w.120w.200.100w

AMA Style

References

  1. National Library of Medicine. Apolipoprotein A-I. Medical Subject Headings (MeSH). 2026. Unique ID D016632. http://id.nlm.nih.gov/mesh/2026/D016632
  2. Apolipoprotein A-I. In: Wikipedia. https://en.wikipedia.org/wiki/Apolipoprotein_AI
  3. Apolipoprotein A-I. In: Wikidata. https://www.wikidata.org/wiki/Q1316030