Chemicals and Drugs

Apolipoprotein E4

A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

7 entry terms
  • Apo E epsilon 4
  • Apo E-4
  • Apo E4
  • ApoE4
  • Apolipoprotein E-4
  • Apo E 4
  • Apolipoprotein E 4

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007 (1982)

MeSH Record

Previous Indexing

  • Apolipoproteins E (1982-2006)

MeSH Hierarchy

Tree Numbers

  1. D10w.532w.091w.500w.750
  2. D12.776w.070.400w.500w.750
  3. D12.776w.521w.120w.500w.750

AMA Style

References

  1. National Library of Medicine. Apolipoprotein E4. Medical Subject Headings (MeSH). 2026. Unique ID D053327. http://id.nlm.nih.gov/mesh/2026/D053327
  2. Apolipoprotein E4. In: Wikidata. https://www.wikidata.org/wiki/Q76614433