Chemicals and Drugs

Apoptosis Inducing Factor

A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

5 entry terms
  • AIF Apoptosis Regulatory Protein
  • Apoptosis-Inducing Factor
  • Mitochondrial Apoptosis-Inducing Factor
  • Apoptosis-Inducing Factor, Mitochondrial
  • Mitochondrial Apoptosis Inducing Factor

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

INHIBITOR OF APOPTOSIS PROTEINS is also available

MeSH Record

History Note

2006(1999)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.682w.608.047w
  2. D12.644w.360.075.311w
  3. D12.776w.157w.687.063w
  4. D12.776w.331w.161w
  5. D12.776w.476.075.311w
  6. D12.776w.660w.720.063w

AMA Style

References

  1. National Library of Medicine. Apoptosis Inducing Factor. Medical Subject Headings (MeSH). 2026. Unique ID D051033. http://id.nlm.nih.gov/mesh/2026/D051033
  2. Apoptosis Inducing Factor. In: Wikipedia. https://en.wikipedia.org/wiki/Apoptosis-inducing_factor
  3. Apoptosis Inducing Factor. In: Wikidata. https://www.wikidata.org/wiki/Q4780529