Structured Summary
Abstract
Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES).
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Aspects Covered
27 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
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History Note
2003
MeSH Record
Previous Indexing
- Phenanthrenes (1965-2002)
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References
- National Library of Medicine. Aristolochic Acids. Medical Subject Headings (MeSH). 2026. Unique ID D034341. http://id.nlm.nih.gov/mesh/2026/D034341
- Aristolochic Acids. In: Wikipedia. https://en.wikipedia.org/wiki/Aristolochic_acid
- Aristolochic Acids. In: Wikidata. https://www.wikidata.org/wiki/Q424210