Chemicals and Drugs

Artesunate

A water-soluble, semi-synthetic derivative of the sesquiterpene lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A water-soluble, semi-synthetic derivative of the sesquiterpene lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities

Chemical Identity

Chemical Information

Molecular Formula
C19H28O8
Molecular Weight
384.4 g/mol
CAS Registry No.
88495-63-0
IUPAC Name
4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid
InChIKey
FIHJKUPKCHIPAT-AHIGJZGOSA-N
SMILES
C[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC(=O)CCC(=O)O)C
MeSH Unique ID
D000077332
Source
PubChem CID 6917864

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • Dihydroartemisinine-12-alpha-succinate
  • Malacef
  • Malartin
  • SM 804
  • SM-804
  • Sodium Artesunate
  • Succinyl Dihydroartemisinin
  • Dihydroartemisinin, Succinyl
  • Dihydroartemisinine 12 alpha succinate
  • SM804

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1983)

MeSH Hierarchy

Tree Numbers

  1. D01w.339w.431w.125.500w
  2. D02w.389w.593w.187.500w
  3. D02w.455w.849w.765w.211.500w

AMA Style

References

  1. National Library of Medicine. Artesunate. Medical Subject Headings (MeSH). 2026. Unique ID D000077332. http://id.nlm.nih.gov/mesh/2026/D000077332
  2. Artesunate. In: Wikipedia. https://en.wikipedia.org/wiki/Artesunate
  3. Artesunate. In: Wikidata. https://www.wikidata.org/wiki/Q707939
  4. Artesunate. In: PubChem Compound. CID 6917864. https://pubchem.ncbi.nlm.nih.gov/compound/6917864