Chemicals and Drugs

Aryldialkylphosphatase

An enzyme which catalyzes the hydrolysis of an aryl-dialkyl phosphate to form dialkyl phosphate and an aryl alcohol. It can hydrolyze a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. It may also mediate an enzymatic protection of LOW DENSITY LIPOPROTEINS against oxidative modification and the consequent series of events leading to ATHEROMA formation. The enzyme was previously regarded to be identical with Arylesterase (EC 3.1.1.2).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme which catalyzes the hydrolysis of an aryl-dialkyl phosphate to form dialkyl phosphate and an aryl alcohol. It can hydrolyze a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. It may also mediate an enzymatic protection of LOW DENSITY LIPOPROTEINS against oxidative modification and the consequent series of events leading to ATHEROMA formation. The enzyme was previously regarded to be identical with Arylesterase (EC 3.1.1.2).

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

27 entry terms
  • Aryl-dialkyl Phosphatase
  • Arylalkylphosphatase
  • Homocysteine Thiolactone Hydrolase
  • OPA Anhydrase
  • OPH Enzyme
  • Organophosphorus Acid Anhydrase
  • Organophosphorus Acid Anhydrolase
  • Organophosphorus Acid Hydrolase
  • Organophosphorus Hydrolase
  • Paraoxonase
  • Acid Anhydrase, Organophosphorus
  • Acid Anhydrolase, Organophosphorus
  • Acid Hydrolase, Organophosphorus
  • Anhydrase, OPA
  • Anhydrase, Organophosphorus Acid
  • Anhydrolase, Organophosphorus Acid
  • Aryl dialkyl Phosphatase
  • Enzyme, OPH
  • Hydrolase, Homocysteine Thiolactone
  • Hydrolase, Organophosphorus
  • Hydrolase, Organophosphorus Acid
  • Phosphatase, Aryl-dialkyl
  • Thiolactone Hydrolase, Homocysteine
  • Paraoxonase-1
  • Paraoxonase-2
  • Paraoxonase 1
  • Paraoxonase 2

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

entry terms PARAOXONASE-1, and PARAOXONASE-2 see SCR for organism specific terms

MeSH Record

History Note

2004; use ARYLDIALKYLPHOSPHATASE (NM) 1980 - 2003

MeSH Record

Previous Indexing

  • Esterases (1980-2003)

MeSH Hierarchy

Tree Number

  1. D08.811w.277w.352w.660w.500w

AMA Style

References

  1. National Library of Medicine. Aryldialkylphosphatase. Medical Subject Headings (MeSH). 2026. Unique ID D043303. http://id.nlm.nih.gov/mesh/2026/D043303
  2. Aryldialkylphosphatase. In: Wikipedia. https://en.wikipedia.org/wiki/Aryldialkylphosphatase
  3. Aryldialkylphosphatase. In: Wikidata. https://www.wikidata.org/wiki/Q4802705