Structured Summary
Abstract
Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.
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Synonyms
3 entry terms
- Asialoglycoprotein
- Desialylated Glycoproteins
- Glycoproteins, Desialylated
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
85
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Previous Indexing
- Glycoproteins (1966-1984)
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References
- National Library of Medicine. Asialoglycoproteins. Medical Subject Headings (MeSH). 2026. Unique ID D001212. http://id.nlm.nih.gov/mesh/2026/D001212
- Asialoglycoproteins. In: Wikipedia. https://en.wikipedia.org/wiki/Asialoglycoprotein
- Asialoglycoproteins. In: Wikidata. https://www.wikidata.org/wiki/Q1134444