Chemicals and Drugs

Atorvastatin

A pyrrole and heptanoic acid derivative, HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITOR (statin), and ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL; APOLIPOPROTEIN B; and TRIGLYCERIDES. It is used to increase serum levels of HDL-CHOLESTEROL in the treatment of HYPERLIPIDEMIAS, and for the prevention of CARDIOVASCULAR DISEASES in patients with multiple risk factors.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A pyrrole and heptanoic acid derivative, HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITOR (statin), and ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL; APOLIPOPROTEIN B; and TRIGLYCERIDES. It is used to increase serum levels of HDL-CHOLESTEROL in the treatment of HYPERLIPIDEMIAS, and for the prevention of CARDIOVASCULAR DISEASES in patients with multiple risk factors.

Chemical Identity

Chemical Information

Molecular Formula
C33H35FN2O5
Molecular Weight
558.6 g/mol
CAS Registry No.
134523-00-5
IUPAC Name
(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
InChIKey
XUKUURHRXDUEBC-KAYWLYCHSA-N
SMILES
CC(C)C1=C(C(=C(N1CC[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4
MeSH Unique ID
D000069059
Source
PubChem CID 60823

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

11 entry terms
  • (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid
  • Atorvastatin Calcium
  • Atorvastatin Calcium Anhydrous
  • Atorvastatin Calcium Hydrate
  • Atorvastatin Calcium Trihydrate
  • Atorvastatin, Calcium Salt
  • CI 981
  • CI-981
  • Lipitor
  • Liptonorm
  • CI981

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1990)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.129w.578.075w
  2. D10w.251w.450w.200w

AMA Style

References

  1. National Library of Medicine. Atorvastatin. Medical Subject Headings (MeSH). 2026. Unique ID D000069059. http://id.nlm.nih.gov/mesh/2026/D000069059
  2. Atorvastatin. In: Wikipedia. https://en.wikipedia.org/wiki/Atorvastatin
  3. Atorvastatin. In: Wikidata. https://www.wikidata.org/wiki/Q668093
  4. Atorvastatin. In: PubChem Compound. CID 60823. https://pubchem.ncbi.nlm.nih.gov/compound/60823