Chemicals and Drugs

Atrasentan

A pyrrolidine and benzodioxole derivative that acts a RECEPTOR, ENDOTHELIN A antagonist. It has therapeutic potential as an antineoplastic agent and for the treatment of DIABETIC NEPHROPATHIES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A pyrrolidine and benzodioxole derivative that acts a RECEPTOR, ENDOTHELIN A antagonist. It has therapeutic potential as an antineoplastic agent and for the treatment of DIABETIC NEPHROPATHIES.

Chemical Identity

Chemical Information

Molecular Formula
C29H38N2O6
Molecular Weight
510.6 g/mol
CAS Registry No.
173937-91-2
IUPAC Name
(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
InChIKey
MOTJMGVDPWRKOC-QPVYNBJUSA-N
SMILES
CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1C2=CC=C(C=C2)OC)C(=O)O)C3=CC4=C(C=C3)OCO4
MeSH Unique ID
D000077868
Source
PubChem CID 159594

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

16 entry terms
  • (11C)ABT-627
  • 2-(4-Methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(((dibutylamino)carbonyl)methyl)pyrrolidine-3-carboxylic acid
  • A 127722
  • A 147627
  • A-127722
  • A-127722.5
  • A-147627
  • ABT 627
  • ABT-627
  • Atrasentan Hydrochloride
  • Xinlay
  • A 127722.5
  • A127722
  • A127722.5
  • A147627
  • ABT627

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1996)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.246.118.300w
  2. D03w.383.773.079w
  3. D03w.633.100.115.300w

AMA Style

References

  1. National Library of Medicine. Atrasentan. Medical Subject Headings (MeSH). 2026. Unique ID D000077868. http://id.nlm.nih.gov/mesh/2026/D000077868
  2. Atrasentan. In: Wikipedia. https://en.wikipedia.org/wiki/Atrasentan
  3. Atrasentan. In: Wikidata. https://www.wikidata.org/wiki/Q125083
  4. Atrasentan. In: PubChem Compound. CID 159594. https://pubchem.ncbi.nlm.nih.gov/compound/159594