Diseases

Autoimmune Experimental Encephalomyelitis

An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

12 entry terms
  • Allergic Encephalomyelitis, Experimental
  • Autoimmune Encephalomyelitis, Experimental
  • Encephalomyelitis, Autoimmune, Experimental
  • Encephalomyelitis, Experimental Autoimmune
  • Experimental Allergic Encephalomyelitis
  • Experimental Autoimmune Encephalomyelitis
  • Encephalomyelitis, Autoimmune Experimental
  • Encephalomyelitis, Experimental Allergic
  • Experimental Allergic Encephalomyelitides
  • Experimental Encephalomyelitis, Autoimmune
  • Allergic Encephalomyelitis
  • Encephalomyelitis, Allergic

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

coordinate with specific demyelinating disease if pertinent

MeSH Record

History Note

2005 (1964)

MeSH Hierarchy

Tree Numbers

  1. C10w.114.703.300w
  2. C10w.228w.140w.695w.562w.250w
  3. C10w.314w.350w.250w
  4. C20w.111w.258.625.300w
  5. E05.598.500w.500.500w

MeSH Record

NLM Classification

WL 351

AMA Style

References

  1. National Library of Medicine. Autoimmune Experimental Encephalomyelitis. Medical Subject Headings (MeSH). 2026. Unique ID D004681. http://id.nlm.nih.gov/mesh/2026/D004681
  2. Autoimmune Experimental Encephalomyelitis. In: Wikipedia. https://en.wikipedia.org/wiki/Experimental_autoimmune_encephalomyelitis
  3. Autoimmune Experimental Encephalomyelitis. In: Wikidata. https://www.wikidata.org/wiki/Q494066