Diseases

Autoimmune Experimental Neuritis

An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

15 entry terms
  • Allergic Neuritis, Experimental
  • Autoimmune Neuritis, Experimental
  • EAN (Experimental Allergic Neuritis)
  • EAN (Experimental Autoimmune Neuritis)
  • Experimental Allergic Neuritis
  • Experimental Autoimmune Neuritis
  • Experimental Autoimmune Neuropathy
  • Neuritis, Autoimmune, Experimental
  • Neuritis, Experimental Allergic
  • Neuritis, Experimental Autoimmune
  • Autoimmune Neuropathies, Experimental
  • Autoimmune Neuropathy, Experimental
  • Experimental Autoimmune Neuropathies
  • Neuropathies, Experimental Autoimmune
  • Neuropathy, Experimental Autoimmune

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

coordinate with GUILLAINE-BARRE SYNDROME if pertinent

MeSH Record

History Note

2005 (1982)

MeSH Record

Previous Indexing

  • Myelin Sheath (1966-1981)
  • Neuritis (1966-1981)
  • Peripheral Nerves (1966-1981)

MeSH Hierarchy

Tree Numbers

  1. C10w.114.703.700
  2. C10w.668w.829w.650w.500
  3. C20w.111w.258.625.700
  4. E05.598.500w.500.875

MeSH Record

NLM Classification

WL 544

AMA Style

References

  1. National Library of Medicine. Autoimmune Experimental Neuritis. Medical Subject Headings (MeSH). 2026. Unique ID D009444. http://id.nlm.nih.gov/mesh/2026/D009444
  2. Autoimmune Experimental Neuritis. In: Wikidata. https://www.wikidata.org/wiki/Q55092977