Structured Summary
Abstract
A UBIQUITIN-like modifier protein that functions in AUTOPHAGOSOME formation, CYTOPLASM to VACUOLE transport, MITOPHAGY, and nucleophagy. Conjugation with ATG5 PROTEIN or ATG10 is essential for its function. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme for lipid modification of ATG8 FAMILY PROTEINS and their localization to vesicle membranes.
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Synonyms
5 entry terms
- ATG12 Protein
- Ubiquitin-Like Protein ATG12
- ATG12, Ubiquitin-Like Protein
- Autophagy Related Protein 12
- Ubiquitin Like Protein ATG12
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Small Ubiquitin-Related Modifier Proteins (2008-2016)
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AMA Style
References
- National Library of Medicine. Autophagy-Related Protein 12. Medical Subject Headings (MeSH). 2026. Unique ID D000071192. http://id.nlm.nih.gov/mesh/2026/D000071192
- Autophagy-Related Protein 12. In: Wikidata. https://www.wikidata.org/wiki/Q24742233