Chemicals and Drugs

Autophagy-Related Protein 7

An autophagy related protein that is similar to UBIQUITIN-ACTIVATING ENZYME E1. It functions in CYTOPLASM to VACUOLE transport (Cvt) and AUTOPHAGY by activating ATG12 PROTEIN for its conjugation with ATG5 PROTEIN, as well as the conjugation of ATG8 FAMILY PROTEINS with phosphatidylethanolamine for ATG8 association to Cvt vesicles and AUTOPHAGOSOME membranes. It is also required for the nitrogen starvation response in yeast, MITOPHAGY; and autophagic cell death induced by CASPASE 8 inhibition.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An autophagy related protein that is similar to UBIQUITIN-ACTIVATING ENZYME E1. It functions in CYTOPLASM to VACUOLE transport (Cvt) and AUTOPHAGY by activating ATG12 PROTEIN for its conjugation with ATG5 PROTEIN, as well as the conjugation of ATG8 FAMILY PROTEINS with phosphatidylethanolamine for ATG8 association to Cvt vesicles and AUTOPHAGOSOME membranes. It is also required for the nitrogen starvation response in yeast, MITOPHAGY; and autophagic cell death induced by CASPASE 8 inhibition.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

8 entry terms
  • ATG12-Activating Enzyme E1 ATG7
  • ATG7 Protein
  • Ubiquitin-Activating Enzyme E1-like Protein
  • Ubiquitin-Like Modifier-Activating Enzyme ATG7
  • ATG12 Activating Enzyme E1 ATG7
  • Autophagy Related Protein 7
  • Ubiquitin Activating Enzyme E1 like Protein
  • Ubiquitin Like Modifier Activating Enzyme ATG7

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Microtubule-Associated Proteins (2005-2016)
  • Ubiquitin-Activating Enzymes (2006-2016)

MeSH Hierarchy

Tree Number

  1. D12.776w.094.399

AMA Style

References

  1. National Library of Medicine. Autophagy-Related Protein 7. Medical Subject Headings (MeSH). 2026. Unique ID D000071193. http://id.nlm.nih.gov/mesh/2026/D000071193
  2. Autophagy-Related Protein 7. In: Wikidata. https://www.wikidata.org/wiki/Q24721402