Structured Summary
Abstract
A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.
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Classification
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Synonyms
5 entry terms
- Axin Signaling Complex Proteins
- beta-Catenin Destruction Complex
- Destruction Complex, beta-Catenin
- Signaling Complex, Axin
- beta Catenin Destruction Complex
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2012
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Axin Signaling Complex. Medical Subject Headings (MeSH). 2026. Unique ID D060465. http://id.nlm.nih.gov/mesh/2026/D060465
- Axin Signaling Complex. In: Wikidata. https://www.wikidata.org/wiki/Q14883310