Chemicals and Drugs

Azacosterol

Diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase, which causes the accumulation of desmosterol.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase, which causes the accumulation of desmosterol.

Chemical Identity

Chemical Information

Molecular Formula
C25H44N2O
Molecular Weight
388.6 g/mol
CAS Registry No.
313-05-3
IUPAC Name
(3S,8R,9S,10R,13S,14S,17S)-17-[3-(dimethylamino)propyl-methylamino]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
InChIKey
FMTFZYKYVZBISL-HUVRVWIJSA-N
SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2N(C)CCCN(C)C)CC=C4[C@@]3(CC[C@@H](C4)O)C
MeSH Unique ID
D001373
Source
PubChem CID 10023199

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

5 entry terms
  • 20,25-Diazacholesterol
  • 20,25 Diazacholesterol
  • Diazacholesterol Dihydrochloride
  • SC 12937
  • Dihydrochloride, Diazacholesterol

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(78); was see under CHOLESTEROL 1978-90

MeSH Record

Previous Indexing

  • Aza Compounds (1972-1977)
  • Cholesterol (1966-1977)

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.247.222w.284w.070w
  2. D04w.210.500w.247.808w.197w.070w
  3. D10w.570w.938w.208w.070w

AMA Style

References

  1. National Library of Medicine. Azacosterol. Medical Subject Headings (MeSH). 2026. Unique ID D001373. http://id.nlm.nih.gov/mesh/2026/D001373
  2. Azacosterol. In: Wikipedia. https://en.wikipedia.org/wiki/Azacosterol
  3. Azacosterol. In: Wikidata. https://www.wikidata.org/wiki/Q4832015
  4. Azacosterol. In: PubChem Compound. CID 10023199. https://pubchem.ncbi.nlm.nih.gov/compound/10023199