Structured Summary
Abstract
A costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN. It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
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Synonyms
12 entry terms
- Antigen, B7-2
- Antigens, CD86
- B7-2 Costimulatory Molecule
- B70 Costimulatory Molecule
- CD86 Antigen
- CD86 Antigens
- Early T Cell Costimulatory Molecule 1
- Antigen, B7 2
- Antigen, CD86
- B7 2 Antigen
- Costimulatory Molecule, B7-2
- Costimulatory Molecule, B70
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2018 (1993)
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References
- National Library of Medicine. B7-2 Antigen. Medical Subject Headings (MeSH). 2026. Unique ID D051940. http://id.nlm.nih.gov/mesh/2026/D051940
- B7-2 Antigen. In: Wikipedia. https://en.wikipedia.org/wiki/CD86
- B7-2 Antigen. In: Wikidata. https://www.wikidata.org/wiki/Q5009846