Structured Summary
Abstract
An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
10 entry terms
- ATG-6 Protein
- ATG6 Protein
- Beclin-1 Protein
- Beclin1
- Coiled-coil Myosin-like Bcl2-interacting Protein
- GT197 Protein
- ATG 6 Protein
- Beclin 1
- Beclin 1 Protein
- Coiled coil Myosin like Bcl2 interacting Protein
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Apoptosis Regulatory Proteins (2006-2016)
- Membrane Proteins (2006-2016)
MeSH Hierarchy
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AMA Style
References
- National Library of Medicine. Beclin-1. Medical Subject Headings (MeSH). 2026. Unique ID D000071186. http://id.nlm.nih.gov/mesh/2026/D000071186
- Beclin-1. In: Wikidata. https://www.wikidata.org/wiki/Q24786747