Structured Summary
Abstract
A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
11 entry terms
- Bestrophin
- Bestrophin Family
- Bestrophin Proteins
- BEST-1 Protein
- BEST-2 Protein
- Bestrophin-1
- Bestrophin-2
- BEST 1 Protein
- BEST 2 Protein
- Bestrophin 1
- Bestrophin 2
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Chloride Channels (1999-2017)
- Eye Proteins (1999-2017)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Bestrophins. Medical Subject Headings (MeSH). 2026. Unique ID D000075002. http://id.nlm.nih.gov/mesh/2026/D000075002
- Bestrophins. In: Wikidata. https://www.wikidata.org/wiki/Q24720439