Disciplines and Occupations

Bioisosterism

A strategy used in PHARMACEUTIC CHEMISTRY where one part of a molecule is replaced with a different one that has similar physical or chemical properties, but with the aim of enhancing the biological activity, stability, or safety of the molecule.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A strategy used in PHARMACEUTIC CHEMISTRY where one part of a molecule is replaced with a different one that has similar physical or chemical properties, but with the aim of enhancing the biological activity, stability, or safety of the molecule.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

11 entry terms
  • Bioisosteric Design
  • Bioisosteric Modification
  • Bioisosteric Replacement
  • Bioisosteric Substitution
  • Bioisosteric Modifications
  • Bioisosteric Replacements
  • Bioisosteric Substitutions
  • Design, Bioisosteric
  • Modification, Bioisosteric
  • Replacement, Bioisosteric
  • Substitution, Bioisosteric

MeSH Record

Aspects Covered

10 allowable subheadings

Indexed with the subheadings classification, economics, ethics, history, instrumentation, methods, standards, statistics & numerical data, trends, veterinary.

MeSH Record

History Note

2026

MeSH Record

Previous Indexing

  • Structure-Activity Relationship (1985-2025)

MeSH Hierarchy

Tree Number

  1. H01w.158w.703w.007.001

AMA Style

References

  1. National Library of Medicine. Bioisosterism. Medical Subject Headings (MeSH). 2026. Unique ID D000099120. http://id.nlm.nih.gov/mesh/2026/D000099120
  2. Bioisosterism. In: Wikidata. https://www.wikidata.org/wiki/Q137655917