Chemicals and Drugs

Biopterins

Pterin derivatives based on 2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone. Biopterins are natural products that have been considered as growth factors for some insects. Biopterins are cofactors for the AROMATIC AMINO ACID hydroxylases and NITRIC OXIDE SYNTHASE. Deficiencies in BIOPTERINS metabolism (e.g., lowered TETRAHYDROBIOPTERIN) are associated with neurological deterioration (e.g., HYPERPHENYLALANINAEMIA).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Pterin derivatives based on 2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone. Biopterins are natural products that have been considered as growth factors for some insects. Biopterins are cofactors for the AROMATIC AMINO ACID hydroxylases and NITRIC OXIDE SYNTHASE. Deficiencies in BIOPTERINS metabolism (e.g., lowered TETRAHYDROBIOPTERIN) are associated with neurological deterioration (e.g., HYPERPHENYLALANINAEMIA).

Chemical Identity

Chemical Information

Molecular Formula
C9H11N5O3
Molecular Weight
237.22 g/mol
CAS Registry No.
22150-76-1
IUPAC Name
2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-3H-pteridin-4-one
InChIKey
LHQIJBMDNUYRAM-DZSWIPIPSA-N
SMILES
C[C@@H]([C@@H](C1=CN=C2C(=N1)C(=O)NC(=N2)N)O)O
MeSH Unique ID
D001708
Source
PubChem CID 135403659

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

19 entry terms
  • 2-Amino-6-((1S,2R)-1,2-dihydroxypropyl)-4(1H)-pteridinone
  • 2-Amino-6-((1S,2S)-1,2-dihydroxypropyl)-4(1H)-pteridinone
  • 2-Amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone
  • 2-Amino-6-(1,2-dihydroxypropyl)-4(8H)-pteridinone
  • 2-amino-6-((1R,2R)-1,2-dihydroxypropyl)-4(3H)-pteridinone
  • 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-, (S-(R*,S*))-
  • 6-Biopterin
  • Biopterin
  • D-threo-Biopterin
  • Dictyopterin
  • L-Biopterin
  • L-erythro-Biopterin
  • L-threo-Biopterin
  • Orinapterin
  • 6 Biopterin
  • D threo Biopterin
  • L Biopterin
  • L erythro Biopterin
  • L threo Biopterin

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

/defic /physiol permitted

MeSH Record

History Note

2024(1987); use PTERIDINES 1975-1986

MeSH Record

Previous Indexing

  • Propanediols (1972-1974)
  • Pteridines (1970-1974)

MeSH Hierarchy

Tree Numbers

  1. D03w.633.100.733.631.202w
  2. D08.211w.090w

MeSH Record

NLM Classification

QU 135

AMA Style

References

  1. National Library of Medicine. Biopterins. Medical Subject Headings (MeSH). 2026. Unique ID D001708. http://id.nlm.nih.gov/mesh/2026/D001708
  2. Biopterins. In: Wikipedia. https://en.wikipedia.org/wiki/Biopterin
  3. Biopterins. In: Wikidata. https://www.wikidata.org/wiki/Q408256
  4. Biopterins. In: PubChem Compound. CID 135403659. https://pubchem.ncbi.nlm.nih.gov/compound/135403659