Chemicals and Drugs

Bispecific Antibodies

Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

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See Also

MeSH Record

Synonyms

6 entry terms
  • Antibodies, Bispecific
  • Bifunctional Antibodies
  • Antibodies, Bifunctional
  • Bispecific Monoclonal Antibodies
  • Antibodies, Bispecific Monoclonal
  • Monoclonal Antibodies, Bispecific

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

do not coordinate with ANTIBODY FORMATION for /biosynthesis

MeSH Record

History Note

94

MeSH Record

Previous Indexing

  • Antibodies (1985-1993)
  • specific Antibodies (1985-1993)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.486.485.114w.125
  2. D12.776w.124w.790.651.114w.134
  3. D12.776w.377w.715.548.114w.134

AMA Style

References

  1. National Library of Medicine. Bispecific Antibodies. Medical Subject Headings (MeSH). 2026. Unique ID D018033. http://id.nlm.nih.gov/mesh/2026/D018033
  2. Bispecific Antibodies. In: Wikidata. https://www.wikidata.org/wiki/Q76120612