Chemicals and Drugs

Buserelin

A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.

Chemical Identity

Chemical Information

Molecular Formula
C60H86N16O13
Molecular Weight
1239.4 g/mol
CAS Registry No.
57982-77-1
IUPAC Name
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
InChIKey
CUWODFFVMXJOKD-UVLQAERKSA-N
SMILES
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6
MeSH Unique ID
D002064
Source
PubChem CID 50225

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

11 entry terms
  • Bigonist
  • Buserelin Acetate
  • HOE-766
  • Profact
  • Receptal
  • Suprecur
  • Suprefact
  • Tiloryth
  • Acetate, Buserelin
  • HOE 766
  • HOE766

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

92; was BUSERELIN ACETATE 1984-91; BUSERELIN was see BUSERELIN ACETATE 1984-91

MeSH Record

Previous Indexing

  • FSH (1966-1973)
  • LH (Luteinizing Hormone) (1966-1973)
  • LH-FSH Releasing Hormone/analogs & derivatives (1974-1983)
  • Pituitary Hormone Releasing Hormones (1968-1973)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.327.740.320w.100w
  2. D12.644w.400w.400.740.320w.100w
  3. D12.644w.456w.460w.150w
  4. D12.644w.548w.365.740.320w.100w
  5. D12.776w.631w.650w.405.740.320w.100w

AMA Style

References

  1. National Library of Medicine. Buserelin. Medical Subject Headings (MeSH). 2026. Unique ID D002064. http://id.nlm.nih.gov/mesh/2026/D002064
  2. Buserelin. In: Wikipedia. https://en.wikipedia.org/wiki/Buserelin
  3. Buserelin. In: Wikidata. https://www.wikidata.org/wiki/Q414745
  4. Buserelin. In: PubChem Compound. CID 50225. https://pubchem.ncbi.nlm.nih.gov/compound/50225