Chemicals and Drugs

CCCTC-Binding Factor

A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

5 entry terms
  • CTCF Protein
  • DNA-Binding Protein CTCF
  • CCCTC Binding Factor
  • CTCF, DNA-Binding Protein
  • DNA Binding Protein CTCF

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1998)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.687.157
  2. D12.776w.260w.120
  3. D12.776w.660w.235.050
  4. D12.776w.660w.720.157
  5. D12.776w.664w.235.050
  6. D12.776w.930w.780.563

AMA Style

References

  1. National Library of Medicine. CCCTC-Binding Factor. Medical Subject Headings (MeSH). 2026. Unique ID D000076246. http://id.nlm.nih.gov/mesh/2026/D000076246
  2. CCCTC-Binding Factor. In: Wikidata. https://www.wikidata.org/wiki/Q5014546