Chemicals and Drugs

COP9 Signalosome Complex

A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

20 entry terms
  • COP9 Signalosome (CSN)
  • COP9 Signalsome
  • Constitutive Photomorphogenesis 9 Signalosome
  • Constitutive Photomorphogenesis 9 Signalsome
  • Signalosome Complex, COP9
  • Signalsome, COP9
  • COP9 Signalosome Subunit 1
  • COP9 Signalosome Subunit 2
  • COP9 Signalosome Subunit 3
  • COP9 Signalosome Subunit 4
  • COP9 Signalosome Subunit 5
  • COP9 Signalosome Subunit 6
  • COP9 Signalosome Subunit 7A
  • COP9 Signalosome Subunit 7B
  • COP9 Signalosome Subunit 8
  • FUSCA Protein 11
  • G Protein Pathway Suppressor 1
  • Sgn3
  • Signalosome Subunit 3
  • Subunit 3, Signalosome

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1995); for COP9 SIGNALOSOME SUBUNIT 3 use SIGNALOSOME SUBUNIT 3 1998-2017

MeSH Hierarchy

Tree Numbers

  1. D05.500w.139w
  2. D08.811w.037w.750.250w
  3. D08.811w.277w.656w.300w.887.375w

AMA Style

References

  1. National Library of Medicine. COP9 Signalosome Complex. Medical Subject Headings (MeSH). 2026. Unique ID D000075686. http://id.nlm.nih.gov/mesh/2026/D000075686
  2. COP9 Signalosome Complex. In: Wikipedia. https://en.wikipedia.org/wiki/COP9_signalosome
  3. COP9 Signalosome Complex. In: Wikidata. https://www.wikidata.org/wiki/Q14905184