Chemicals and Drugs

Calicheamicins

Enediyne aminoglycosides derived from the bacterium MICROMONOSPORA ECHINOSPORA that are used as antineoplastic antibiotics. They bind to DNA in both healthy and tumor cells, resulting in strand scission and cell death.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Enediyne aminoglycosides derived from the bacterium MICROMONOSPORA ECHINOSPORA that are used as antineoplastic antibiotics. They bind to DNA in both healthy and tumor cells, resulting in strand scission and cell death.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

1 entry terms
  • Calicheamicin

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2020

MeSH Record

Previous Indexing

  • Aminoglycosides (1989-2019)
  • Enediynes (2007-2019)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.326.271w.244w.250w
  2. D02w.455w.326.397w.680w.500.500w.250w
  3. D09w.408w.051.247w

AMA Style

References

  1. National Library of Medicine. Calicheamicins. Medical Subject Headings (MeSH). 2026. Unique ID D000080084. http://id.nlm.nih.gov/mesh/2026/D000080084
  2. Calicheamicins. In: Wikipedia. https://en.wikipedia.org/wiki/Calicheamicin
  3. Calicheamicins. In: Wikidata. https://www.wikidata.org/wiki/Q409744