Chemicals and Drugs

Calmodulin

A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

24 entry terms
  • Calcium-Dependent Activator Protein
  • Calcium-Dependent Regulator
  • Phosphodiesterase Activating Factor
  • Phosphodiesterase Activator Protein
  • Phosphodiesterase Protein Activator
  • Regulator, Calcium-Dependent
  • Activating Factor, Phosphodiesterase
  • Activator Protein, Calcium-Dependent
  • Activator Protein, Phosphodiesterase
  • Activator, Phosphodiesterase Protein
  • Calcium Dependent Activator Protein
  • Calcium Dependent Regulator
  • Factor, Phosphodiesterase Activating
  • Protein Activator, Phosphodiesterase
  • Protein, Calcium-Dependent Activator
  • Protein, Phosphodiesterase Activator
  • Regulator, Calcium Dependent
  • Bovine Activator Protein
  • Cyclic AMP-Phosphodiesterase Activator
  • AMP-Phosphodiesterase Activator, Cyclic
  • Activator Protein, Bovine
  • Activator, Cyclic AMP-Phosphodiesterase
  • Cyclic AMP Phosphodiesterase Activator
  • Protein, Bovine Activator

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

a calcium-binding protein; /biosyn /physiol permitted

MeSH Record

History Note

84; was CALCIUM-DEPENDENT REGULATOR see under CALCIUM-BINDING PROTEINS 1980-83; was CALCIUM-DEPENDENT REGULATOR see under CARRIER PROTEINS 1979

MeSH Record

Previous Indexing

  • Calcium (1966-1978)
  • Carrier Proteins (1971-1978)
  • Enzyme Activation (1969-1978)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.372w.249w
  2. D12.776w.157w.125w.412w.249w
  3. D12.776w.476.387w.249w

MeSH Record

NLM Classification

QU 55.2

AMA Style

References

  1. National Library of Medicine. Calmodulin. Medical Subject Headings (MeSH). 2026. Unique ID D002147. http://id.nlm.nih.gov/mesh/2026/D002147
  2. Calmodulin. In: Wikipedia. https://en.wikipedia.org/wiki/Calmodulin
  3. Calmodulin. In: Wikidata. https://www.wikidata.org/wiki/Q409145