Chemicals and Drugs

Calreticulin

A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

10 entry terms
  • 55-kDa High-Affinity Calcium Binding Protein
  • CAB-63
  • CBP3 (Liver)
  • Calcium-Binding Protein-3
  • Calregulin
  • ERp60
  • HACBP
  • cC1qR Protein
  • 55 kDa High Affinity Calcium Binding Protein
  • Calcium Binding Protein 3

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use CALRETICULIN (NM) 1990-2002

MeSH Record

Previous Indexing

  • Calcium-Binding Proteins (1990-2002)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.372w.374w
  2. D12.776w.157w.125w.412w.374w
  3. D12.776w.476.387w.374w
  4. D12.776w.503w.303w

AMA Style

References

  1. National Library of Medicine. Calreticulin. Medical Subject Headings (MeSH). 2026. Unique ID D037282. http://id.nlm.nih.gov/mesh/2026/D037282
  2. Calreticulin. In: Wikipedia. https://en.wikipedia.org/wiki/Calreticulin_protein_family
  3. Calreticulin. In: Wikidata. https://www.wikidata.org/wiki/Q24787491