Structured Summary
Abstract
A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
Chemical Identity
Chemical Information
- Molecular Formula
- C10H12O4
- Molecular Weight
- 196.20 g/mol
- CAS Registry No.
- 56-25-7
- IUPAC Name
- (1S,2R,6S,7R)-2,6-dimethyl-4,10-dioxatricyclo[5.2.1.02,6]decane-3,5-dione
- InChIKey
- DHZBEENLJMYSHQ-XCVPVQRUSA-N
- SMILES
- C[C@@]12[C@H]3CC[C@@H]([C@@]1(C(=O)OC2=O)C)O3
- MeSH Unique ID
- D002193
- Source
- PubChem CID 5944
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
2 entry terms
- Cantharidine
- Cantharides
MeSH Record
Aspects Covered
19 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analogs & derivatives, analysis, chemical synthesis, chemistry, classification, economics, history, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity.
MeSH Record
History Note
79; was CANTHARIDES 1963-78
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Cantharidin. Medical Subject Headings (MeSH). 2026. Unique ID D002193. http://id.nlm.nih.gov/mesh/2026/D002193
- Cantharidin. In: Wikipedia. https://en.wikipedia.org/wiki/Cantharidin
- Cantharidin. In: Wikidata. https://www.wikidata.org/wiki/Q410884
- Cantharidin. In: PubChem Compound. CID 5944. https://pubchem.ncbi.nlm.nih.gov/compound/5944