Chemicals and Drugs

Cathepsin C

A papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays a role in the activation of several pro-inflammatory serine proteases by removal of their aminoterminal inhibitory dipeptides. Genetic mutations that cause loss of cathepsin C activity in humans are associated with PAPILLON-LEFEVRE DISEASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays a role in the activation of several pro-inflammatory serine proteases by removal of their aminoterminal inhibitory dipeptides. Genetic mutations that cause loss of cathepsin C activity in humans are associated with PAPILLON-LEFEVRE DISEASE.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

3 entry terms
  • Dipeptidyl Aminopeptidase I
  • Dipeptidyl Peptidase I
  • Dipeptidyl Transferase

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2010(1981)

MeSH Record

Previous Indexing

  • Dipeptidyl Peptidases (1984-1999)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.224w.130
  2. D08.811w.277w.656w.262w.186
  3. D08.811w.277w.656w.350w.350.100

AMA Style

References

  1. National Library of Medicine. Cathepsin C. Medical Subject Headings (MeSH). 2026. Unique ID D020789. http://id.nlm.nih.gov/mesh/2026/D020789
  2. Cathepsin C. In: Wikidata. https://www.wikidata.org/wiki/Q5052480