Chemicals and Drugs

Cefotetan

A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.

Chemical Identity

Chemical Information

Molecular Formula
C17H17N7O8S4
Molecular Weight
575.6 g/mol
IUPAC Name
(7S)-7-[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChIKey
SRZNHPXWXCNNDU-PGEKIEPBSA-N
SMILES
CN1C(=NN=N1)SCC2=C(N3C([C@@](C3=O)(NC(=O)C4SC(=C(C(=O)N)C(=O)O)S4)OC)SC2)C(=O)O
MeSH Unique ID
D015313
Source
PubChem CID 50614

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

15 entry terms
  • Apacef
  • Apatef
  • Cefotan
  • Cefotetan Disodium
  • Cefotetan Disodium Salt
  • Ceftotan
  • ICI-156834
  • YM-09330
  • Disodium Salt, Cefotetan
  • Disodium, Cefotetan
  • ICI 156834
  • ICI156834
  • Salt, Cefotetan Disodium
  • YM 09330
  • YM09330

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • Cephamycins (1982-1988)

MeSH Hierarchy

Tree Numbers

  1. D02w.065w.589w.099w.249w.250w.199w
  2. D02w.886w.665w.074w.250w.199w
  3. D03w.383.129w.617.235w
  4. D03w.633.100.300w.249w.250w.199w

AMA Style

References

  1. National Library of Medicine. Cefotetan. Medical Subject Headings (MeSH). 2026. Unique ID D015313. http://id.nlm.nih.gov/mesh/2026/D015313
  2. Cefotetan. In: Wikipedia. https://en.wikipedia.org/wiki/Cefotetan
  3. Cefotetan. In: Wikidata. https://www.wikidata.org/wiki/Q2602246
  4. Cefotetan. In: PubChem Compound. CID 50614. https://pubchem.ncbi.nlm.nih.gov/compound/50614